IL-2 Protéine

N° du produit ABIN988056

Cette protéine Recombinant IL-2 est exprimée dans et a été mentionnée dans 2+ publications.

Aperçu rapide pour IL-2 Protéine (ABIN988056)

Antigène: IL-2 (IL2) (Interleukin 2 (IL2))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Hôte: Veuillez nous consulter SVP

Pureté: > 98 % as determined by the following methods:(a) SEC-HPLC analysis(b) Reducing and non-reducing SDS-PAGE silver-stained gel analysis

Détail du produit

Séquence: analysis The sequence of the first five N-terminal amino acids has been found to be Met-Pro-Thr-Ser-Ser. p to grams level.

Attributs du produit: The specific activity as determined and was found to be greater than 1.0×107 IU/mg.

niveau d'endotoxine: Level Less than 0.1 ng/myg (1 IEU/myg) determined by LAL tes

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is recommended to reconstitute the lyophilized Recombinant Human Interleukin-2 (IL-2) in sterile 18 M-omega-cm H2O not less than 100 myg/ml, which can then be further diluted to other aqueous solutions.

Stock: -20 °C

Référence

Webster, Zufferey, Pane, Coulson: "Alteration of the thymic T cell repertoire by rotavirus infection is associated with delayed type 1 diabetes development in non-obese diabetic mice." dans: PLoS ONE, Vol. 8, Issue 3, pp. e59182, (2013) (PubMed).

Suzuki, Jagger, Konya, Shimojima, Pryshchep, Goronzy, Weyand: "CD8+CD45RA+CCR7+FOXP3+ T cells with immunosuppressive properties: a novel subset of inducible human regulatory T cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 5, pp. 2118-30, (2012) (PubMed).

Détail du antigène

Antigène: IL-2 (IL2) (Interleukin 2 (IL2))

Autre désignation: Interleukin-2 (IL-2)

Sujet: In vitro studies performed on human cell lines demonstrate the immunoregulatory properties of Interleukin-2 (IL-2) including: 1) enhancement of lymphocyte mitogenesis and stimulation of long-term growth of human Interleukin-2 (IL-2) dependent edll lines, 2) enhancement of lymphocyte cytotoxicity, 3) induction of killer cell (lymphokine-activated (LAK) and natural (NK)) activity, 4) induction of interferon-gamma production. Human Interleukin-2 (IL-2) is a highly purified protein with a molecular weight of approximately 15,300 Da. The chemical name is des-alanyl-1, serine-125 human interleukin-2. It is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human Human Interleukin-2 (IL-2) gene. Genetic engineering techniques were used to modify the human Interleukin-2 (IL-2) gene, and the resulting expression clone encodes a modified human Interleukin-2 (IL-2). This recombinant form differs from native Interleukin-2 (IL-2) in following ways: 1) it is not glycosylated, 2) the molecule has no N-terminal alanine, 3) the molecule has serine substituted for cysteine at amino acid position 125, 4) the aggregation state of molecule is likely to be different from that of native Interleukin-2 (IL-2). Synonym: rHuIL-2, rHuIL2 zoom, Interleukin-2, Interleukin. Formulation: The protein was lyophilized after extensive dialysis against 50mM Phosphate buffer, pH7.5, 5% Mannitol buffer.

Poids moléculaire: 15,300 Da Isoelectric Point The main zone between 6.5-7.5 analysis by IEF

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation